Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377698 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
In this investigation, a practical green chemistry procedure for synthesis of octahydroquinazolinone according to the Biginelli reaction using 5,5-dimethyl-1,3-cyclohexanedione, urea or thiourea, and appropriate aromatic aldehydes in the presence of two drops of concentrated H2SO4 as a catalyst is described in water. This methodology is of interest due to the use of water as a solvent without use of any organic solvent and toxic metals as catalyst, thus minimizing the cost, the operational hazards, and environmental pollution. Also this modified route provides much higher yields and simple work-up procedure of products.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Zahra Hassani, Mohammad Reza Islami, Maryam Kalantari,