| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377701 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A prodrug of paclitaxel which has a coumarin derivative conjugated to the amino acid moiety of isotaxel (O-acyl isoform of paclitaxel) has been synthesized. The prodrug was selectively converted to isotaxel by visible light irradiation (430 nm) with the cleavage of coumarin. Finally, paclitaxel was released by subsequent spontaneous O–N intramolecular acyl migration.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Mariusz Skwarczynski, Mayo Noguchi, Shun Hirota, Youhei Sohma, Tooru Kimura, Yoshio Hayashi, Yoshiaki Kiso,