| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377708 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
In order to define new PPARβ/δ ligands, SAR study on the selective PPARβ/δ activator L-165,041 led to the identification of one key functional group for selective PPARβ/δ activation. Furthermore, taking advantage of SAR studies done elsewhere on the most selective PPARβ/δ ligand GW501516, the conception of new ligands showing good affinity for PPARβ/δ is reported. Finally, synthesis and biological evaluation of pyridine analogues have shown the benefical effect of the pyridine ring on the PPARβ/δ subtype selectivity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Carine Ekambomé Basséne, Franck Suzenet, Nathalie Hennuyer, Bart Staels, Daniel-Henri Caignard, Catherine Dacquet, Pierre Renard, Gérald Guillaumet,