| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377716 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
The 4-amino-5-azaindole as an amidino-benzimidazole replacement is described. A series of potent and selective analogs were discovered and showed desirable ex vivo efficacy as measured by PT.
Graphical abstractIn our continued effort to develop orally bioavailable factor VIIa inhibitors based on the 2-[5-(5-carbamimidoyl-1H-benzoimidazol-2-yl)-6-hydroxy-biphenyl-3-yl]- succinic acid scaffold, we have identified potent and selective analogs with 4-amino-5-azaindole (1H-pyrrolo[3,2-c]pyridin-4-ylamine) as a less basic amidine replacement.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
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Authors
Huiyong Hu, Aleksandr Kolesnikov, Jennifer R. Riggs, Kieron E. Wesson, Robin Stephens, Ellen M. Leahy, William D. Shrader, Paul A. Sprengeler, Michael J. Green, Ellen Sanford, Margaret Nguyen, Erik Gjerstad, Ronnel Cabuslay, Wendy B. Young,