| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377717 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
In present investigation, 2-(4-formyl-2-methoxyphenoxy) acetic acid on condensation with various ketones in methanolic KOH solution yielded the corresponding chalcones (1–3). These corresponding chalcones were reacted with appropriate acid hydrazide in glacial acetic acid led to the formation of phenoxy acetic acid derivatives. All newly synthesized compounds were evaluated for their anti-mycobacterial activities against Mycobacterium tuberculosis H37Rv.
Graphical abstractIn the present investigation, 2-(4-formyl-2-methoxyphenoxy) acetic acid on condensation with various ketones in methanolic KOH solution yielded the corresponding chalcones (1–3). These corresponding chalcones were reacted with appropriate acid hydrazide in glacial acetic acid leading to the formation of phenoxy acetic acid derivatives. All newly synthesized compounds were evaluated for their anti-mycobacterial activities against Mycobacterium tuberculosis H37Rv.Figure optionsDownload full-size imageDownload as PowerPoint slide
