A practical and green approach toward synthesis of N3-substituted dihydropyrimidinones: Using Aza-Michael addition reaction catalyzed by KF/Al2O3

A simple and efficient method for the synthesis of N3-substituted 3,4-dihydropyrimidinones by aza-Michael addition reactions of 3,4-dihydropyrimidinones to α,β-ethylenic compounds catalyzed by KF/Al2O3 is described. The advantage of this method is high regioselectivity, high purity, and the use of a cheaper, milder, and efficient catalyst for the hetero-Michael addition reaction.

Graphical abstractA simple and efficient method for the synthesis of N3-substituted 3,4-dihydropyrimidinones by aza-Michael addition reactions of 3,4-dihydropyrimidinones to α,β-ethylenic compounds catalyzed by KF/Al2O3 is described.Figure optionsDownload full-size imageDownload as PowerPoint slide