Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377722 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A series of 7-diethylaminocoumarin compounds were synthesized and the cytotoxicities were tested against human umbilical vein endothelial cell (HUVEC) and some cancer cells. We found that the introduction of cyano groups at the 4-position will promote the bioactivity. In particular, compounds 9 and 10 strongly inhibited the proliferation of various cancer cell lines, and 12 and 15 showed a high selectivity for HUVEC. Therefore, these coumarin molecules can be utilized as lead compounds to develop potential nontoxic angiogenesis inhibitors and small molecular ligands to target HUVEC.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Seokjoon Lee, Krishnamoorthy Sivakumar, Woon-Seob Shin, Fang Xie, Qian Wang,