Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377726 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Novel analogues of the angiotensin I-converting enzyme (ACE) inhibitor keto-ACE were synthesized via a facile Horner–Emmons olefination of a phosphonoketone precursor with ethyl glyoxylate. Introduction of a bulky aromatic tryptophan at the P2′ position of keto-ACE resulted in a significant increase in C-domain-selectivity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Aloysius T. Nchinda, Kelly Chibale, Pierre Redelinghuys, Edward D. Sturrock,