| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377728 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A series of 3-aryl-4-hydroxyquinolin-2(1H)-ones with fatty acid synthase inhibitory activity was prepared. Starting from a derivative with an IC50 = 1.4 μM, SAR studies led to compounds with more than 70-fold increase in potency (IC50 < 20 nM).
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Alexey Rivkin, Yoona R. Kim, Mark T. Goulet, Nathan Bays, Armetta D. Hill, Ilona Kariv, Stefan Krauss, Nicole Ginanni, Peter R. Strack, Nancy E. Kohl, Christine C. Chung, Jeffrey P. Varnerin, Paul N. Goudreau, Amy Chang, Michael R. Tota, Benito Munoz,