Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377735 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
The synthesis of (±)-epiquinamide 1 and (±)-C(1)-epiepiquinamide 2 based on the use of a Curtius rearrangement to introduce the C(1) amino residue is reported. In a competition binding assay for [3H]epibatidine binding to rat brain membranes neither (±)-1 nor (±)-2 showed any significant level of nicotinic activity.
Graphical abstractThe synthesis of (±)-epiquinamide and (±)-C(1)-epiepiquinamide is reported. In a competition binding assay for [3H]epibatidine binding to rat brain membranes neither ligand showed any significant level of nicotinic activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Akira Kanakubo, Diane Gray, Neal Innocent, Susan Wonnacott, Timothy Gallagher,