| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377740 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
The design and synthesis of a series of potent 1,3,4-trisubstituted-2-oxopiperazine based MC4 agonists are described. The tripeptidomimetics (12a,b and 23) and the dipeptidomimetic 27 displayed single-nanomolar binding affinity and agonist potency for MC4R and excellent selectivity for MC4R relative to MC1R.
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Authors
Xinrong Tian, Rajesh K. Mishra, Adrian G. Switzer, X. Eric Hu, Nick Kim, Adam W. Mazur, Frank H. Ebetino, John A. Wos, Doreen Crossdoersen, Beth B. Pinney, Julie A. Farmer, Russell J. Sheldon,