| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377762 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
N-Hydroxythiosemicarbazide was prepared by two methods starting from 2,4-dimethoxy benzyl amine and hydroxylamine hydrochloride, which in turn was reacted with various aldehydes and ketones to obtain the titled compounds. Eighteen compounds were tested for their in vitro activity against Mycobacterium tuberculosis H37Rv using the agar dilution method. Compound 10p was found to be the most potent compound (MIC: 0.28 μM) and was 2.5 times more active than standard isoniazid.
Graphical abstractEighteen N-hydroxythiosemicarbazones were prepared and tested for their in vitro activity against Mycobacterium tuberculosis H37Rv using the agar dilution method.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dharmarajan Sriram, Perumal Yogeeswari, Prathiba Dhakla, Palaniappan Senthilkumar, Debjani Banerjee,