| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377763 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
The pRBM4 cosmid, which harbors a putative cluster of genes spanning a 31.8-kb chromosomal region of the ribostamycin producer Streptomyces ribosidificus ATCC 21294, was heterologously expressed in Streptomyces lividans TK24. ESI-MS/MS, HPLC, and LC-ESI MS analyses showed that the transformation gave rise to ribostamycin production in various culture broths. This is the first report of heterologous aminoglycoside production.
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Authors
Bimala Subba, Nagendra Prasad Kurumbang, Young Soo Jung, Yeo Joon Yoon, Hei Chan Lee, Kwangkyoung Liou, Jae Kyung Sohng,