| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377766 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A new class of lymphocyte function-associated antigen-1 (LFA-1) antagonists is described. Elaboration of the 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold resulted in the synthesis of potent inhibitors of the LFA-1/ICAM-1 interaction. Along with the in vitro activity, we present the X-ray crystal structure of the complex of compound 9b, in a novel binding mode to the I-domain of LFA-1.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Dharmpal S. Dodd, Steven Sheriff, ChiehYing J. Chang, Dawn K. Stetsko, Linda M. Phillips, Yingru Zhang, Michele Launay, Dominique Potin, Wayne Vaccaro, Michael A. Poss, Murray McKinnon, Joel C. Barrish, Suzanne J. Suchard, T.G. Murali Dhar,