Studies on acyl pyrrolidine inhibitors of HCV RNA-dependent RNA polymerase to identify a molecule with replicon antiviral activity

The SAR development is described for a series of N-acyl pyrrolidine inhibitors of the Hepatitis C virus RNA-dependent RNA polymerase, NS5B, from tractable Δ21 enzyme inhibitors to an example with antiviral activity in a cellular assay (HCV replicon).

Graphical abstractOptimisation of a series of N-acyl pyrrolidine inhibitors of the Hepatitis C Virus RNA-dependent RNA polymerase, NS5B, from tractable enzyme inhibitors to an example with antiviral activity in a cellular assay (HCV replicon).Figure optionsDownload full-size imageDownload as PowerPoint slide