| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377790 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
The synthesis and SAR of tetraazacyclopenta[a]indenes, pharmacokinetic properties and the anxiolytic activity of an orally dosed exemplary compound 9d (Ki 8.0Â nM) are reported.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
![An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes](/preview/png/1377790.png "First Page Preview: An orally active corticotropin releasing factor 1 receptor antagonist from 8-aryl-1,3a,7,8-tetraaza-cyclopenta[a]indenes")
Authors
Xiaojun Han, Rita Civiello, Sokhom S. Pin, Kevin Burris, Lynn A. Balanda, Jay Knipe, Shelly Ren, Tracey Fiedler, Kaitlin E. Browman, Robert Macci, Matthew T. Taber, Jie Zhang, Gene M. Dubowchik,