| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377791 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Optimization of the biological activity for 5,6-diarylpyridines as CB1 receptor inverse agonists is described. Food intake and pharmacokinetic evaluation of 3f and 15c indicate that these compounds are effective orally active modulators of CB1.
Graphical abstractThe synthesis and biological optimization for 5,6-diarylpyridines as CB1 receptor inverse agonists is described.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Christina B. Madsen-Duggan, John S. Debenham, Thomas F. Walsh, Richard B. Toupence, Song X. Huang, Junying Wang, Xinchun Tong, Julie Lao, Tung M. Fong, Marie-Therese Schaeffer, Jing Chen Xiao, Cathy R.-R.C. Huang, Chun-Pyn Shen, D. Sloan Stribling,