| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377795 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Neurodegenerative disorders, such as Alzheimer’s and Parkinson’s diseases, and apoptosis, are thought to be associated with oxidative stress affecting mitochondria. In this study, we designed and synthesized a fluorescein-tagged TEMPO derivative, compound 1, with triphenylphosphino moiety. Synthesized 1 localized in mitochondria and detected oxidative stress in an endotoxic model of a mouse macrophage-like cell line. Compound 1 is therefore a potentially useful probe for evaluating oxidative stress in mitochondria.
Graphical abstractWe designed and synthesized a mitochondria-localizing TEMPO derivative, 1, and demonstrated that synthesized probe 1 localized and detected oxidative stress in mitochondria in an activated mouse macrophage-like cell line.Figure optionsDownload full-size imageDownload as PowerPoint slide
