Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377798 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
Amplification, overexpression, and elevated activation of Akt have been detected in many human malignancies making it an important target for cancer therapy. The Akt substrate-binding site offers a large number of potential interactions to an appropriately designed small molecule and can form the basis for the development of selective inhibitors. Here, we report the progression of GSK3β substrate-mimetic inhibitors towards the development of a potent, small molecule substrate-mimetic inhibitor of Akt.
Graphical abstractThe progression of GSK3β substrate-mimetic inhibitors towards the development of a potent, small molecule substrate-mimetic inhibitor of Akt is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Katherine J. Kayser, Matthew P. Glenn, Said M. Sebti, Jin Q. Cheng, Andrew D. Hamilton,