Article ID Journal Published Year Pages File Type
1377798 Bioorganic & Medicinal Chemistry Letters 2007 6 Pages PDF
Abstract

Amplification, overexpression, and elevated activation of Akt have been detected in many human malignancies making it an important target for cancer therapy. The Akt substrate-binding site offers a large number of potential interactions to an appropriately designed small molecule and can form the basis for the development of selective inhibitors. Here, we report the progression of GSK3β substrate-mimetic inhibitors towards the development of a potent, small molecule substrate-mimetic inhibitor of Akt.

Graphical abstractThe progression of GSK3β substrate-mimetic inhibitors towards the development of a potent, small molecule substrate-mimetic inhibitor of Akt is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Organic Chemistry
Authors
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