| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377799 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
A series of heterobiaryl amides was designed and synthesized as novel mGluR5 antagonists. The synthesis using palladium catalyzed Suzuki–Miyaura cross-coupling reactions provided an array of compounds with a range of in vitro activities. In particular, compound 9e, 4(3,5-difluorophenyl)-N-(6-methylpyridin-1-yl)picolinamide, exhibited nanomolar affinity at the mGluR5 and will serve as a template for future drug design.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Santosh S. Kulkarni, Amy Hauck Newman,