| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377802 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
In order to explore the range of biological activities of the podophyllotoxin compound class, a novel series of derivatives of podophyllotoxin, which were conjugates containing stavudine and different structural podophyllotoxin analogues, were designed, synthesized, and evaluated for their anti-HIV-1 activities in vitro. Among these compounds, 19d and 19c showed the highest anti-HIV-1 activities with EC50 values of 0.17 and 0.29 μM and TI values of 466.9 and 354.5, respectively.
Graphical abstractA novel series of derivatives of podophyllotoxin as anti-HIV-1 agents were synthesized, 19d and 19c showed the highest anti-HIV activity with EC50 values of 0.17 and 0.29 μM and TI values of 466.9 and 354.5, respectively.Figure optionsDownload full-size imageDownload as PowerPoint slide
