| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377816 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A library of acylhydrazone iron chelators was synthesized and tested for its ability to inhibit the growth of a chloroquine-resistant strain of Plasmodium falciparum. Some of these new compounds are significantly more active than desferrioxamine DFO, the iron chelator in widespread clinical use and also than the most effective chelators.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Patricia Melnyk, Virginie Leroux, Christian Sergheraert, Philippe Grellier,