| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377825 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
High throughput screening revealed compound 1 as a potent antagonist of the CCK1 receptor. Evaluation of the CCK1 SAR in a series of these diarylpyrazole antagonists was conducted in a matrix synthesis format revealing additive (Free–Wilson) and non-additive SAR. This use of additive QSAR modeling in conjunction with combinatorial libraries represents a unique approach to the evaluation of SAR interactions between the variables of any combinatorial matrix.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kelly McClure, Michael Hack, Liming Huang, Clark Sehon, Magda Morton, Lina Li, Terrance D. Barrett, Nigel Shankley, J. Guy Breitenbucher,