| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377832 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A novel series of selective HCV NS5B RNA dependent RNA polymerase inhibitors has been disclosed. These compounds contain an appropriately substituted tetrahydrobenzothiophene scaffold. This communication will detail the SAR and activities of this series.
Graphical abstractA series of tetrahydrobenzothiophenes have been prepared and identified as potent inhibitors of HCV NS5B polymerase. R = 6,6-Dimethyl, R′ = CONHSO2Ar.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
M.G. LaPorte, T.A. Lessen, L. Leister, D. Cebzanov, E. Amparo, C. Faust, D. Ortlip, T.R. Bailey, T.J. Nitz, S.K. Chunduru, D.C. Young, C.J. Burns,