Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377836 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
We describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.
Graphical abstractWe describe the identification, SAR, and pharmacology of the src-family selective lck inhibitor A-770041 that prolongs the survival of major histocompatibility mismatched allografts in models of solid organ transplant rejection for greater than 65 days.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Andrew Burchat, David W. Borhani, David J. Calderwood, Gavin C. Hirst, Biqin Li, Robert F. Stachlewitz,