| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377838 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A novel biotin-tagged photoaffinity probe was synthesized and evaluated as a vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor. The probe (2) is a potent VEGFR-2 inhibitor with an IC50 value of 7.1 μM, and inhibits VEGF-induced proliferation in human umbilical vein endothelial cells (HUVEC), with an IC50 value of 40.3 μM. This probe will be a useful reagent for investigating ligand–protein interactions.
Graphical abstractA novel biotin-tagged photoaffinity probe (2) was synthesized and evaluated as a vascular endothelial growth factor receptor-2 (VEGFR-2) tyrosine kinase inhibitor.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sun-Young Han, Seok-Soon Park, Woo Ghil Lee, Yong Ki Min, Bum Tae Kim,