| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377849 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Pulvinones were synthesized (>180) in arrays and evaluated as inhibitors of early stage cell wall biosynthesis enzymes MurA–MurD. Several pulvinones inhibited Mur enzymes with IC50’s in the 1–10 μg/mL range and demonstrated antibacterial activity against Gram-positive bacteria including methicillin-resistant Staphyloccus aureus, vancomycin-resistant Enterococcus faecalis, and penicillin-resistant Streptococcus pneumoniae.
Graphical abstractPulvinones were synthesized (>180) in arrays and evaluated as inhibitors of early stage cell wall biosynthesis enzymes MurA–MurD. Several pulvinones inhibited Mur enzymes with IC50’s in the 1–10 μg/mL range and demonstrated antibacterial activity against Gram-positive bacteria including methicillin-resistant Staphyloccus aureus, vancomycin-resistant Enterococcus faecalis, and penicillin-resistant Streptococcus pneumoniae.Figure optionsDownload full-size imageDownload as PowerPoint slide
