| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377851 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
As part of a detailed study, the syntheses, biological activities, and pharmacokinetic properties of hydroxylated analogues of the previously described broad spectrum antifungal agents, Sch 51048 (1), Sch 50001 (3), and Sch 50002 (4), are described. Based on an overall superior profile, one of the alcohols, Sch 56592 (2), was selected for clinical studies.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5]](/preview/png/1377851.png "First Page Preview: Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5]")
Authors
Frank Bennett, Anil K. Saksena, Raymond G. Lovey, Yi-Tsung Liu, Naginbhai M. Patel, Patrick Pinto, Russel Pike, Edwin Jao, Viyyoor M. Girijavallabhan, Ashit K. Ganguly, David Loebenberg, Haiyan Wang, Anthony Cacciapuoti, Eugene Moss, Fred Menzel,