| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377855 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
The design, synthesis, and activity of novel and selective small molecule antagonists of the CC chemokine receptor-4 (CCR4) are presented. Compound 8c was efficacious in a murine allergic inflammation model (ED50 30 mg/kg).
Graphical abstractThe design, synthesis, and activity of novel and selective small molecule antagonists of the CC chemokine receptor-4 (CCR4) are presented. Compound 8c was efficacious in a murine allergic inflammation model.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ashok V. Purandare, Honghe Wan, Aiming Gao, John Somerville, Christine Burke, Wayne Vaccaro, XiaoXia Yang, Kim W. McIntyre, Michael A. Poss,