| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377920 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Peptides containing Nε-thioacetyl-lysine and Nε-acetyl-lysine were evaluated for their de(thio)acetylation catalyzed by human HDAC8 and SIRT1, two distinct protein deacetylases. Nε-Thioacetyl-lysine was found to be a mimic of Nε-acetyl-lysine for HDAC8-catalyzed reaction, but to confer inhibition against SIRT1. These results point to further diverse applications based on Nε-thioacetyl-lysine.
Graphical abstractPeptides containing Nε-thioacetyl-lysine and Nε-acetyl-lysine were evaluated for their de(thio)acetylation catalyzed by human HDAC8 and SIRT1, two distinct protein deacetylases. Nε-Thioacetyl-lysine was found to be a mimic of Nε-acetyl-lysine for HDAC8-catalyzed reaction, but to confer inhibition against SIRT1.Figure optionsDownload full-size imageDownload as PowerPoint slide
