Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377922 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
A series of N-{1-[(3-thioxo-5,6-dihydroimidazo[2,1-c][1,2,4]thiadiazol-7-ylthio)thiocarbonyl]-2-imidazolidene}arylsulfonamides (2a-z) was obtained by reacting 6,7-dihydro-1H-imidazo[2,1-c][1,2,4]thiadiazol-3-thione (1) with arylsulfonyl chlorides. The relationships between structure and anti-tumor activity revealed that compound 2o with p-Cl substituent at the phenyl ring was most active (âlog GI50 > 8.00, âlog TGI = 7.66) and was found to exhibit high selectivity toward the leukemia CCRF-CEM cell line (Îf = 3.08 and 3.31, respectively).
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
JarosÅaw SÄ
czewski, ZdziaÅaw Brzozowski, Franciszek SÄ
czewski, Patrick J. Bednarski, Manuel Liebeke, Maria Gdaniec,