| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377923 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
Isosteric replacement of the urea group of lead compound 1 led to novel substituted piperidine phenylamide analogues. SAR on the electron-induced effects of various linkers as well as substituents on the phenyl rings and the piperidine nitrogen has been investigated. Many single-digit nanomolar MCH R1 antagonists have been identified from this series.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wen-Lian Wu, Duane A. Burnett, Richard Spring, Li Qiang, Thavalakulamgara K. Sasikumar, Martin S. Domalski, William J. Greenlee, Kim O’Neill, Brian E. Hawes,