| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377924 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
Abstract
Biaryl urea lead compound 1 was discovered earlier in our MCH antagonist program. Novel benzimidazole analogues with increased chemical stability, devoid of the potential carcinogenic liability associated with a biarylamine moiety, were synthesized and evaluated to be potent MCH R1 antagonists. Two compounds in this series have demonstrated in vivo efficacy in a rodent obesity model.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wen-Lian Wu, Duane A. Burnett, Mary Ann Caplen, Martin S. Domalski, Chad Bennett, William J. Greenlee, Brian E. Hawes, Kim O’Neill, Blair Weig, Daniel Weston, Brian Spar, Timothy Kowalski,