| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377935 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
A novel class of cyclophosphamide spiropiperaziniums was synthesized and evaluated for their in vivo anti-cancer activities against S180 and H22. Most of them exhibited definite activities. Especially, compounds 8b and 8k showed good anti-cancer activities, meanwhile, 8k also showed much lower toxicity than CP. Several interesting structure–activity relationships were revealed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Qi Sun, Run-Tao Li, Wei Guo, Jing-Rong Cui, Tie-Ming Cheng, Ze-Mei Ge,