| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377942 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Core sequences necessary for substrate recognition and its inhibition at the PR/p3 site of HTLV-1 protease were clarified for the first time. From the cleavage rates of peptides containing a part of the PR/p3 site, a heptapeptide was found to be the minimal sequence required for substrate recognition. The use of synthetic inhibitors containing hydroxyethylamine dipeptide isostere indicated that a tetrapeptide sequence was necessary to achieve potent inhibition.
Graphical abstractCore sequences necessary for substrate recognition and its inhibition at the PR/p3 site of HTLV-1 protease were clarified.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
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Organic Chemistry
Authors
Hiromi Naka, Kenta Teruya, Jeong Kyu Bang, Saburo Aimoto, Tadashi Tatsumi, Hiroyuki Konno, Kazuto Nosaka, Kenichi Akaji,