Design, synthesis and evaluation of novel uracil amino acid conjugates for the inhibition of Trypanosoma cruzi dUTPase

Potential inhibitors of the Trypanosoma cruzi dUTP nucleotidohydrolase were docked into the enzyme using the program FlexX. Compounds that docked selectively were then selected and synthesized using solid phase methodology, giving rise to a novel library of amino acid uracil acetamide compounds which were evaluated for enzyme inhibition and anti-parasitic activity.

Graphical abstractWe report the in silico design and subsequent synthesis and biological evaluation of a novel class of uracil amino acid conjugates as potential anti-parasitic compounds.Figure optionsDownload full-size imageDownload as PowerPoint slide