| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377955 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Screening of our in-house compound library comprised of intermediates of natural product synthesis projects resulted in discovering two novel γ-secretase inhibitors, which coincidently had similar moieties, that is, cyclohexenone and two aryl groups arranged on the core six-membered ring. Structure–activity relationship studies of these compounds were also developed.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yasuko Takahashi, Haruhiko Fuwa, Akane Kaneko, Makoto Sasaki, Satoshi Yokoshima, Hifumi Koizumi, Tohru Takebe, Toshiyuki Kan, Takeshi Iwatsubo, Taisuke Tomita, Hideaki Natsugari, Tohru Fukuyama,