| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377957 | Bioorganic & Medicinal Chemistry Letters | 2006 | 5 Pages |
The synthesis of several 1-(2-cyano-3-aryl-allyl)-3-aryl-urea(thiourea) constructed from the reaction between allylamines generated from Baylis–Hillman acetates and substituted isocyanates and isothiocyanates has been described. Further, their cyclization in the presence of a base led to the formation of 5-arylmethyl-4-imino-3-aryl-3,4-dihydro-1H-pyrimidin-2-ones. All compounds were tested for their antibacterial activity. Few of the compounds showed superior activity or were equipotent to the standard antibacterial agents.
Graphical abstractThe antibacterial activity of the (thio)ureas and 4-imino-3,4-dihydro-1H-pyrimidin-2-ones obtained from acetyl derivatives of Baylis–Hillman adducts is reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
