| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377958 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Efforts toward developing orally bioavailable factor VIIa inhibitors starting from parenteral lead compound 1 are described. SAR resulted in compound 11 with improved physicochemical properties, leading to enhanced oral absorption in rat.
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dange Vijaykumar, Roopa Rai, Michael Shaghafi, Tony Ton, Steve Torkelson, Ellen M. Leahy, Jennifer R. Riggs, Huiyong Hu, Paul A. Sprengeler, William D. Shrader, Colin O'Bryan, Ronnell Cabuslay, Ellen Sanford, Erik Gjerstadt, Liang Liu,