| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377959 | Bioorganic & Medicinal Chemistry Letters | 2006 | 6 Pages |
Abstract
A series of non-nucleoside HCV NS5B polymerase inhibitors based on the N-1-benzyl or N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine core substituted in the D-ring aromatic moiety have been prepared and evaluated. Aromatic substituents extending from position 7 of the D-ring exhibited excellent potency against both genotypes 1a and 1b.
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![Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring](/preview/png/1377959.png "First Page Preview: Inhibitors of HCV NS5B polymerase: Synthesis and structure–activity relationships of N-1-benzyl and N-1-[3-methylbutyl]-4-hydroxy-1,8-naphthyridon-3-yl benzothiadiazine analogs containing substituents on the aromatic ring")
Authors
Todd W. Rockway, Rong Zhang, Dachun Liu, David A. Betebenner, Keith F. McDaniel, John K. Pratt, David Beno, Debra Montgomery, Wen W. Jiang, Sherie Masse, Warren M. Kati, Tim Middleton, Akhteruzzaman Molla, Clarence J. Maring, Dale J. Kempf,