| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377960 | Bioorganic & Medicinal Chemistry Letters | 2006 | 4 Pages |
Abstract
Previously, chemistry effort on the gem-cyclohexane series of γ-secretase inhibitors has focused on the 4-position of the cyclohexane ring. Recently chemistry has been directed towards the 3-position and substitution here has also provided compounds with high γ-secretase activity.
Graphical abstractThe synthesis, biological activity and conformational analysis of 3-substituted gem-cyclohexanes based on 1 have provided compounds with high γ-secretase activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Richard A. Jelley, Jason Elliott, Karl R. Gibson, Timothy Harrison, Dirk Beher, Earl E. Clarke, Huw D. Lewis, Mark Shearman, Jonathan D.J. Wrigley,