| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377978 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
We describe the identification, SAR, and in vivo pharmacology of a new series of Src-family selective Lck inhibitors. These thienopyridines were designed based on a desire to access the unique residues in the extended hinge region of Lck.
Graphical abstractWe describe the identification, SAR, and in vivo pharmacology of a new series of Src-family selective Lck inhibitors. These thienopyridines were designed to access the unique residues in the extended hinge region of Lck.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lily Abbott, Patrick Betschmann, Andrew Burchat, David J. Calderwood, Heather Davis, Peter Hrnciar, Gavin C. Hirst, Biqin Li, Michael Morytko, Kelly Mullen, Bryant Yang,