Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1377981 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A novel series of spirorifamycins was synthesized and their antibacterial activity evaluated both in vitro and in vivo. This new series of rifamycins shows excellent activity against Staphylococcus aureus that is equivalent to rifabutin. However, some compounds of the series exhibit lower MICs than rifabutin against rifampin-resistant strains of S. aureus. Further, compound 2e exhibits comparable efficacy in vivo in a murine model of S. aureus septicemia model following administration by either oral or parenteral dosing routes.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
In Ho Kim, Keith D. Combrink, Zhenkun Ma, Katrina Chapo, Dalai Yan, Paul Renick, Timothy W. Morris, Mark Pulse, Jerry W. Simecka, Charles Z. Ding,