| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377984 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
A series of azaheterocyclic carbazole sulfonamides was synthesized and evaluated for antiproliferative activity. The most potent compounds N-(2,6-dimethoxypyridine-3-yl)-9-ethyl and 9-methylcarbazole-3-sulfonamide (13 and 14) gave significant cytotoxicity (IC50 = 122 and 101 nM). Compound 13 displayed submicromolar activities against seven human tumor cell lines. The SARs of this series of sulfonamides which includes the influence of azaheterocycle rings, sulfonamide linkage, and the carbazole ring are described.
Graphical abstractCarbazole sulfonamides II showed potent antiproliferative activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Laixing Hu, Zhuo-rong Li, Yue-ming Wang, Yanbin Wu, Jian-Dong Jiang, David W. Boykin,