| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377986 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
Replacement of the carboxylic acid group in a series of previously described 1,5-biaryl pyrrole EP1 receptor antagonists led to the discovery of various novel non-acidic antagonists. Several analogues displayed high binding affinity and high binding efficiency indices.
Graphical abstractThe discovery and SAR of novel non-acidic 1,5-biaryl pyrrole derivatives is described. Several new motifs were discovered that were found to be effective replacements for the carboxylic acid in a series of EP1 receptor antagonists.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Adrian Hall, Stephen Atkinson, Susan H. Brown, Iain P. Chessell, Anita Chowdhury, Gerard M.P. Giblin, Paul Goldsmith, Mark P. Healy, Karamjit S. Jandu, Matthew R. Johnson, Anton D. Michel, Alan Naylor, Jennifer A. Sweeting,