| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377987 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
Aminoglycoside antibiotics target an internal RNA loop within the bacterial ribosomal decoding site. Here, we describe the synthesis and SAR of novel 3,5-diamino-piperidine derivatives as aminoglycoside mimetics, and show they act as inhibitors of bacterial translation and growth.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yuefen Zhou, Vlad E. Gregor, Benjamin K. Ayida, Geoffrey C. Winters, Zhongxiang Sun, Douglas Murphy, Greg Haley, Dwight Bailey, Jamie M. Froelich, Sarah Fish, Stephen E. Webber, Thomas Hermann, Daniel Wall,