| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1377998 | Bioorganic & Medicinal Chemistry Letters | 2007 | 6 Pages |
Abstract
Thirty weak base 1,2,4-dispiro trioxolanes (secondary ozonides) were synthesized. Amino amide trioxolanes had the best combination of antimalarial and biopharmaceutical properties. Guanidine, aminoxy, and amino acid trioxolanes had poor antimalarial activity. Lipophilic trioxolanes were less stable metabolically than their more polar counterparts.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yuanqing Tang, Yuxiang Dong, Sergio Wittlin, Susan A. Charman, Jacques Chollet, Francis C.K. Chiu, William N. Charman, Hugues Matile, Heinrich Urwyler, Arnulf Dorn, Saroj Bajpai, Xiaofang Wang, Maniyan Padmanilayam, Jean M. Karle, Reto Brun,