| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378000 | Bioorganic & Medicinal Chemistry Letters | 2007 | 4 Pages |
Abstract
Carbonic anhydrase inhibitors AZA, EZA, and 4-acetamidobenzsulfonamide were found to inhibit human AQP4-M23 mediated water transport by 80%, 68%, and 23%, respectively, at 20 μM in an in vitro functional assay. AZA was found to have an IC50 against AQP4 of 0.9 μM. Phloretin was inactive under the same conditions.
Graphical abstractA series of carbonic anhydrase inhibitors, including AZA, have been found to inhibit AQP4 mediated water transport in an in vitro functional assay. AZA has an apparent IC50 = 0.9 μM against human AQP4-M23.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Vincent J. Huber, Mika Tsujita, Maya Yamazaki, Kenji Sakimura, Tsutomu Nakada,