| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1378022 | Bioorganic & Medicinal Chemistry Letters | 2007 | 5 Pages |
Abstract
A three-component condensation of 5-amino-3-methylpyrazole, tetronic acid, and various aromatic, heteroaromatic, and aliphatic aldehydes leads to the formation of dihydropyridopyrazole analogues of a cytotoxic lignan podophyllotoxin. This new heterocyclic scaffold-based library allows a drastic reduction of the structural complexity of the natural product with the retention of its potent cytotoxic properties. Similarly to podophyllotoxin, the presented analogues induce apoptosis in Jurkat cells.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Igor V. Magedov, Madhuri Manpadi, Elena Rozhkova, Nikolai M. Przheval’skii, Snezna Rogelj, Scott T. Shors, Wim F.A. Steelant, Severine Van slambrouck, Alexander Kornienko,