Quinazoline and benzimidazole MCH-1R antagonists

We have modified the previously reported 2-aminoquinoline 1 to provide two novel series of MCH-1R antagonists. Representative compounds from the quinazoline and benzimidazole series have been shown to be potent and selective, with promising in vitro eADME profiles.

Graphical abstractThe discovery, synthesis, evaluation and structure–activity relationships of a series of quinazolines and benzimidazoles as MCH-1R antagonists are described.Figure optionsDownload full-size imageDownload as PowerPoint slide